Movement preparation in Parkinson's disease Time course and distribution of movement-related potentials in a movement precueing task
Identifieur interne : 002093 ( Main/Exploration ); précédent : 002092; suivant : 002094Movement preparation in Parkinson's disease Time course and distribution of movement-related potentials in a movement precueing task
Auteurs : P. Praamstra [Pays-Bas] ; A. S. Meyer [Pays-Bas] ; A. R. Cools [Pays-Bas] ; M. W. I. M. Horstink [Pays-Bas] ; D. F. Stegeman [Pays-Bas]Source :
- Brain [ 0006-8950 ] ; 1996-10.
Abstract
Summary Investigations of the effects of advance information on movement preparation in Parkinson's disease using reaction time (RT) measures have yielded contradictory results. In order to obtain direct information regarding the time course of movement preparation, we combined RT measurements in a movement precueing task with multi-channel recordings of movement-related potentials in the present study. Movements of the index and middle fingers of the left and right hand were either precued or not by advance information regarding the side (left or right hand) of the required response. Reaction times were slower for patients than for control subjects. Both groups benefited equally from informative precues, indicating that patients utilized the advance information as effectively as control subjects. Lateralization of the movement-preceding cerebral activity [i.e. the lateralized readiness potential (LRP)] confirmed that patients used the available partial information to prepare their responses and started this process no later than controls. In conjunction with EMG onset times, the LRP onset measures allowed for a fractionation of the RTs, which provided clues to the stages where the slowness of Parkinson's disease patients might arise. No definite abnormalities of temporal parameters were found, but differences in the distribution of the lateralized movement-preceding activity between patients and controls suggested differences in the cortical organization of movement preparation. Differences in amplitude of the contingent negative variation (CNV) and differences in the way in which the CNV was modulated by the information given by the precue pointed in the same direction. A difference in amplitude of the P300 between patients and controls suggested that preprogramming a response required more effort from patients than from control subjects.
Url:
DOI: 10.1093/brain/119.5.1689
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Movement preparation in Parkinson's disease Time course and distribution of movement-related potentials in a movement precueing task</title><author><name sortKey="Praamstra, P" sort="Praamstra, P" uniqKey="Praamstra P" first="P." last="Praamstra">P. Praamstra</name></author><author><name sortKey="Meyer, A S" sort="Meyer, A S" uniqKey="Meyer A" first="A. S." last="Meyer">A. S. Meyer</name></author><author><name sortKey="Cools, A R" sort="Cools, A R" uniqKey="Cools A" first="A. R." last="Cools">A. R. Cools</name></author><author><name sortKey="Horstink, M W I M" sort="Horstink, M W I M" uniqKey="Horstink M" first="M. W. I. M." last="Horstink">M. W. I. M. Horstink</name></author><author><name sortKey="Stegeman, D F" sort="Stegeman, D F" uniqKey="Stegeman D" first="D. F." last="Stegeman">D. F. Stegeman</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6FC96F9417874A00398A04FFEC37D8DD016D2E59</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1093/brain/119.5.1689</idno><idno type="url">https://api.istex.fr/document/6FC96F9417874A00398A04FFEC37D8DD016D2E59/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001984</idno><idno type="wicri:Area/Main/Curation">001733</idno><idno type="wicri:Area/Main/Exploration">002093</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Movement preparation in Parkinson's disease Time course and distribution of movement-related potentials in a movement precueing task</title><author><name sortKey="Praamstra, P" sort="Praamstra, P" uniqKey="Praamstra P" first="P." last="Praamstra">P. Praamstra</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute of Neurology Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Meyer, A S" sort="Meyer, A S" uniqKey="Meyer A" first="A. S." last="Meyer">A. S. Meyer</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Max Planck Institute for Psycholinguistics Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Cools, A R" sort="Cools, A R" uniqKey="Cools A" first="A. R." last="Cools">A. R. Cools</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychoneuropharmacology, University of Nijmegen Nijmegen</wicri:regionArea><wicri:noRegion>University of Nijmegen Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Horstink, M W I M" sort="Horstink, M W I M" uniqKey="Horstink M" first="M. W. I. M." last="Horstink">M. W. I. M. Horstink</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute of Neurology Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Stegeman, D F" sort="Stegeman, D F" uniqKey="Stegeman D" first="D. F." last="Stegeman">D. F. Stegeman</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute of Neurology Nijmegen</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1996-10">1996-10</date><biblScope unit="volume">119</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1689">1689</biblScope><biblScope unit="page" to="1704">1704</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">6FC96F9417874A00398A04FFEC37D8DD016D2E59</idno><idno type="DOI">10.1093/brain/119.5.1689</idno><idno type="ArticleID">119.5.1689</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Summary Investigations of the effects of advance information on movement preparation in Parkinson's disease using reaction time (RT) measures have yielded contradictory results. In order to obtain direct information regarding the time course of movement preparation, we combined RT measurements in a movement precueing task with multi-channel recordings of movement-related potentials in the present study. Movements of the index and middle fingers of the left and right hand were either precued or not by advance information regarding the side (left or right hand) of the required response. Reaction times were slower for patients than for control subjects. Both groups benefited equally from informative precues, indicating that patients utilized the advance information as effectively as control subjects. Lateralization of the movement-preceding cerebral activity [i.e. the lateralized readiness potential (LRP)] confirmed that patients used the available partial information to prepare their responses and started this process no later than controls. In conjunction with EMG onset times, the LRP onset measures allowed for a fractionation of the RTs, which provided clues to the stages where the slowness of Parkinson's disease patients might arise. No definite abnormalities of temporal parameters were found, but differences in the distribution of the lateralized movement-preceding activity between patients and controls suggested differences in the cortical organization of movement preparation. Differences in amplitude of the contingent negative variation (CNV) and differences in the way in which the CNV was modulated by the information given by the precue pointed in the same direction. A difference in amplitude of the P300 between patients and controls suggested that preprogramming a response required more effort from patients than from control subjects.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Praamstra, P" sort="Praamstra, P" uniqKey="Praamstra P" first="P." last="Praamstra">P. Praamstra</name></noRegion><name sortKey="Cools, A R" sort="Cools, A R" uniqKey="Cools A" first="A. R." last="Cools">A. R. Cools</name><name sortKey="Horstink, M W I M" sort="Horstink, M W I M" uniqKey="Horstink M" first="M. W. I. M." last="Horstink">M. W. I. M. Horstink</name><name sortKey="Meyer, A S" sort="Meyer, A S" uniqKey="Meyer A" first="A. S." last="Meyer">A. S. Meyer</name><name sortKey="Stegeman, D F" sort="Stegeman, D F" uniqKey="Stegeman D" first="D. F." last="Stegeman">D. F. Stegeman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002093 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002093 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:6FC96F9417874A00398A04FFEC37D8DD016D2E59
|texte= Movement preparation in Parkinson's disease Time course and distribution of movement-related potentials in a movement precueing task
}}
| This area was generated with Dilib version V0.6.23. |  |